Table 1.
Compositions, hydrodynamic sizes and zeta potentials of Gd-liposomes with oligoethylene glycol shielding (A, B, C), stealth lipid shielding (D) and without PEG shielding (E, F, G).
| Liposome | DOPE | Gd-lipid | PEG-lipid | DOTMA | FL-DHPE | DLS (PDI) | Zeta |
|---|---|---|---|---|---|---|---|
| A | 9% | 30% Gd-DEG1SL | 50% DODEG4 | 10% | 1% | 96.8 nm (0.2) | (+) 62 mV |
| B | 9% | 30% Gd-DEG3SL | 50% DODEG4 | 10% | 1% | 92.9 nm (0.2) | (+) 56 mV |
| C | 9% | 30% Gd-DEG6SL | 50% DODEG4 | 10% | 1% | 177 nm (0.2) | (+) 56 mV |
| D | 2% | 30% Gd-DEG3SL | 7% DSPE-PEG2000 | 60% | 1% | 146 nm (0.3) | (+) 45 mV |
| E | 9% | 30% Gd-DEG1SL | – | 60% | 1% | 212.9 nm (0.3) | (+) 55 mV |
| F | 9% | 30% Gd-DEG3SL | – | 60% | 1% | 220.8 nm (0.4) | (+) 53 mV |
| G | 9% | 30% Gd-DEG6SL | – | 60% | 1% | 244.4 nm (0.3) | (+) 44 mV |