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. Author manuscript; available in PMC: 2012 Dec 12.
Published in final edited form as: Ann N Y Acad Sci. 2010 Jan;1183:149–157. doi: 10.1111/j.1749-6632.2009.05134.x

Figure 2. PKB/Foxo dependent regulation of KLF2 and its target genes.

Figure 2

Naive T cells contain low levels of PI(3,4,5)P3 and active PKB. In these cells Foxo transcription factors are actively inducing the expression of targets genes such as KLF2. KLF2 in turn induces the expression of an array of genes that determine T cell trafficking, CD62L, CCR7 and S1P1. In contrast, in effector T cells, activated PI3-Kinase maintains elevated levels of PI(3,4,5)P3 and resultant activated PKB. PKB phosphorylates Foxo transcription factors on multiple residues maintaining them within the cytosol, thus repressing KLF2 expression and that of its target genes.