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Determination of the binding affinities of compounds 2, 3 and the Smac AVPI peptide to (A). XIAP BIR3; (B). cIAP1 BIR3; and (C). cIAP2 BIR3 using sensitive and quantitative fluorescence-polarization assays. The standard deviation for the IC50 value to each protein was calculated from three independent experiments.
