Table 1.

Pharmacokinetic properties of compound 2 in four different species.

Species	Route	Dose (mg/kg)	AUC (0-t) (hr*μg/mL)	Cmax (μg/mL)	T1/2 (hr)	F%
Mice	i.v.	10	3.8		3.0
	p.o.	30	4.3	1.2	2.3	38
Rats	i.v.	5	1.1 ± 0.1	-	1.4 ± 0.2
	p.o.	25	2.3 ± 0.7	0.66 ± 0.27	1.8 0.3	45
NHP	i.v.	2.5	17.9 ±11.0		6.3 ± 0.4
	p.o.	5	13.5 ± 7.9	2.2 ± 0.6	5.4 ± 1.0	42
Dogs	i.v.	5	81.6 ±17.3		16.3 ± 3.8
	p.o.	10	90.3 ± 23.5	8.5 ± 2.5	27.1 ± 13.7	55