Table 1.
Characteristics of the three patient clusters derived from HCAa
| Cluster 1 (n = 17) | Cluster 2 (n = 9) | Cluster 3 (n = 14) | Single outlier | |
|---|---|---|---|---|
| TERalb (%/h) | 13.88 ± 9.23 | 9.12 ± 5.29b | 17.29 ± 9.11 | 3 |
| Age (years) | 62.1 ± 17.2 | 61.4 ± 19.2 | 60.3 ± 15.7 | 60 |
| Gender (M, %) | 65 | 56 | 36 | M |
| BMI (kg/m2) | 26.1 ± 5.7 | 25.8 ± 3.9 | 28.3 ± 5.1 | 25.1 |
| PD duration (months) | 22.9 ± 20.3 | 27.6 ± 21.0 | 26.8 ± 21.2 | 10.5 |
| Solute transport (4 h D/P creatinine ratio) | 0.81 ± 0.13 | 0.78 ± 0.12 | 0.74 ± 0.17 | 0.7 |
| Albumin (g/L) | 29.1 ± 4.9c | 31.3 ± 3.3 | 33.2 ± 4.1 | 33 |
| CRP (mg/L) | 14.3 (4.8–21)d | 1.5 (0.6–4) | 4.6 (0.8–9.5) | 16.8 |
| Peritoneal Pcl (mL/day) | 95.6 ± 48.3 | 67.3 ± 21.7 | 69.0 ± 24.7 | 64.04 |
| Peritoneal protein loss (g/24 h) | 6.3 ± 3.2 | 4.9 ± 1.6 | 5.0 ± 1.8 | 4.28 |
| Urine protein loss (g/24 h) | 0.58 ± 0.5 | 0.88 ± 0.85 | 0.74 ± 0.51 | 1.12 |
| Total protein loss (g/24 h) | 7.11 ± 3.00 | 6.06 ± 2.06 | 6.02 ± 2.07 | 5.4 |
| Urine volume (mL) | 709 ± 631 | 1128 ± 626 | 1059 ± 759 | 997 |
| Adjusted PV (mL/m2) | 1439 ± 300 | 1441 ± 173 | 1446 ± 197 | 2158 |
| TBWD/Weight | 0.51 ± 0.04 | 0.53 ± 0.07b | 0.47 ± 0.06 | 0.52 |
| TBWBIA/Weight | 0.45 ± 0.05 | 0.53 ± 0.08d,e | 0.45 ± 0.06 | 0.56 |
| TBWD/Weight − TBWBIA/Weight | 0.049 ± 0.041 | 0.006 ± 0.025f | 0.023 ± 0.055 | − 0.046 |
| Ever smoked (%) | 44 | 22 | 23 | Yes |
| IHD (%) | 41 | 22 | 29 | No |
| Diabetes (%) | 17 | 22 | 50 | No |
aAdjusted PV, plasma volume adjusted by body surface area; BMI, body mass index; Pcl, protein clearance corrected for dialysis regime (modality, dry day and overfill); TBWD/Weight, TBW normalized to body weight as determined from deuterium (D) dilution; TBWBIA/Weight, TBW normalized to body weight as estimated by BIA. Clusters 1, 2 and 3 were compared using one-way analysis of variance (ANOVA) and when significant the post hoc between group differences are shown.
bCluster 2 versus Cluster 3, P < 0.05.
cCluster 1 versus Cluster 3, P < 0.05.
dCluster 1 versus Cluster 2, P < 0.01.
eCluster 2 versus Cluster 3, P < 0.01.
fCluster 1 versus Cluster 2, P < 0.05 (ANOVA).