. 2012 Dec 11;3(6):e00407-12. doi: 10.1128/mBio.00407-12

TABLE 2 .

Select overlapping targets in ChIP-chip and transcriptome analyses

Bound region in ChIP-chip	Overlapped target with transcriptome profiling	Effect of Crp induction on target transcription	Function
Secondary metabolism
SCO3217^a	SCO3217	Activated	CdaR, pathway-specific activator; CDA synthesis
SCO3229^a	SCO3229	Activated	HmaS, 4-hydroxymandelate synthase
	SCO3230	Activated	CdaPSI, CDA peptide synthetase I
SCO3230^a	SCO3230	Activated	CdaPSI, CDA peptide synthetase I
SCO5085 (1)^b	SCO5085	Activated	ActII-4, pathway-specific activator; Act synthesis
SCO5085 (2)^b	SCO5085	Activated	ActII-4, pathway-specific activator; Act synthesis
SCO5221-5222	SCO5222	Repressed	EizA, putative lyase
SCO5223	SCO5223	Repressed	Putative cytochrome P450
SCO6271-6272^c	SCO6271	Activated	AccA1, acyl-CoA carboxylase complex; yCPK synthesis
	SCO6272	Activated	Scf, secreted FAD^d-binding protein; yCPK synthesis
SCO6272^c	SCO6272	Activated	Scf, secreted FAD-binding protein; yCPK synthesis
SCO6275-6276^c	SCO6275	Activated	CpkA, type I polyketide synthase; yCPK synthesis
SCO6429	SCO6429	Activated	Putative NRPS
Primary metabolism
SCO4561-4562 (1)	SCO4562	Repressed	NuoA, NADH dehydrogenase subunit
SCO4921-4922	SCO4921	Activated	AccA2, acyl-CoA carboxylase complex A subunit
SCO4978-4979	SCO4979	Activated	PckA, phosphoenolpyruvate carboxykinase
SCO5260-5261	SCO5260	Activated	NADP⁺-dependent malic enzyme

^{^a}

Secondary metabolic gene cluster for calcium-dependent antibiotic.

^{^b}

Secondary metabolic gene cluster for actinorhodin.

^{^c}

Secondary metabolic gene cluster for cryptic polyketide.

^{^d}

FAD, flavin adenine dinucleotide.