Figure 1.

A summary of the possible molecular and pathophysiological roles that ABCC6 plays in the ectopic calcification as seen in pseudoxanthoma elasticum, β-thalassemia, generalized arterial calcification of infancy, dystrophic cardiac calcification, and other cardiovascular diseases.

Abbreviations:

CAD

Coronary Artery Diseases

CVD

Cardiovascular Diseases

ECM

extracellular matrix

GAG

Glycoaminoglycans

MGP

Matrix Gla Protein

MI

Myocardial Infarction

PAD

Peripheral Arterial Disease

PPi

pyrophosphate

SMC

Smooth Muscle Cells.