Table II.
Hormones and fat measures in 116 survivors of childhood acute lymphoblastic leukemia, by gender and history of treatment with cranial radiotherapy (CRT).
| Entire Cohort | Females | Males | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Females | Males | p | CRT | No CRT | p | CRT | No CRT | p | |
| N=64 | N=52 | N=24 | N=40 | N=15 | N=37 | ||||
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | ||||
| HOMA-IR* | 4.3 (2.5) | 4.1 (2.5) | 0.56 | 5.2 (2.7) | 3.7 (2.1) | 0.01 | 4.8 (3.6) | 3.7 (2.0) | 0.49 |
| Leptin per kg fat (ng/mL/kg) | 0.7 (0.3) | 0.4 (0.2) | <0.01 | 0.9 (0.3) | 0.7 (0.3) | 0.1 | 0.5 (0.3) | 0.3 (0.2) | 0.01 |
| Adiponectin per kg fat (μg/mL/kg) | 0.6 (0.4) | 0.8 (0.7) | 0.75 | 0.4 (0.3) | 0.8 (0.5) | <0.01 | 0.6 (0.7) | 0.8 (0.6) | 0.02 |
| Leptin to adiponectin ratio | 2.2 (1.9) | 1.2 (1.9) | <0.01 | 3.0 (2.1) | 1.7 (1.7) | <0.01 | 2.2 (3.0) | 0.8 (1.1) | 0.01 |
| Truncal to lower body fat ratio | 1.2 (0.3) | 1.4 (0.4) | <0.01 | 1.4 (0.4) | 1.0 (0.3) | <0.01 | 1.6 (0.5) | 1.4 (0.3) | 0.04 |
| Total body fat (% mass) | 37.7 (7.5) | 23.6 (8.6) | <0.01 | 42.6 (4.9) | 34.6 (7.2) | 0.01 | 28.5 (6.3) | 21.7 (8.7) | 0.05 |
| Lean body mass (kg) | 43.7 (7.8) | 59.7 (9.1) | <0.01 | 42.3 (9.6) | 44.6 (6.5) | 0.22 | 56.8 (11.1) | 60.8 (8.1) | 0.21 |
| Waist: height ratio | 0.6 (0.1) | 0.5 (0.1) | <0.01 | 0.6 (0.1) | 0.5 (0.1) | <0.01 | 0.6 (0.1) | 0.5 (0.1) | 0.09 |
| Body mass index (kg/m2) | 28.7 (7.8) | 26.7 (5.6) | 0.21 | 31.7 (8.6) | 26.9 (6.8) | 0.01 | 27.8 (7.5) | 26.2 (4.5) | 0.54 |
| Waist circumference (cm) | 92.3 (16.6) | 90.8 (13.5) | 0.84 | 96.5 (16.7) | 89.9 (16.2) | 0.09 | 94.6 (16.3) | 89.2 (12.1) | 0.21 |
*
HOMA-IR: Homeostasis model of insulin resistance