Fig 6.

Effects of p38 and JNK MAP kinase inhibitors on UVB-induced expression of antioxidant enzymes. Undifferentiated and differentiated keratinocytes were incubated with SB203580 (10 μM), a p38 MAP kinase inhibitor, or SP600125 (20 μM), a JNK MAP kinase inhibitor, for 3 h and then exposed to UVB or control at the indicated doses. After 24 h, RNA was extracted from the cells and analyzed for mRNA expression by real-time PCR (n = 3−6, ±SE). Data are presented as fold change in gene expression relative to unexposed undifferentiated cells. Differences were considered statistically significant at P < 0.05: ^ap38 kinase inhibitor treatment versus control and ^bJNK inhibitor treatment versus control.