Table 2.
Main brain pharmacokinetic parameters of the non-compartmental model in mice after intravenous, intranasal, or oral administration
| Group | C max (μg/g) | T max (min) | AUC0–120 min (μg∙g−1·min) | MRT0–120 min (min) | Re (%) | Te (%) | DTI |
| i.v. | 43.02±5.11 | 1 | 505.34±82.91 | 20.47±8.83 | 100 | 79.92 | 1 |
| i.n. | 8.96±1.37** | 3.4 | 345.48±69.94* | 49.00±8.27** | 68.37 | 60.25 | 0.75 |
| p.o. | 8.54±1.96** | 10 | 194.03±23.46** | 43.63±17.07** | 38.40 | 71.38 | 0.89 |
C max: calculated maximum concentration; T max: time corresponding to C max; AUC0–120 min: partial area under the curve from 0 to 120 min; MRT0–120 min: mean residence time from 0 to 120 min; Re: relative brain targeted coefficient; Te: brain/blood drug ratio; DTI: the drug target index; i.v.: intravenous administration; i.n.: intranasal administration; p.o.: oral administration. Data are expressed as mean±SD (n=5)
*
P<0.05 compared with the intravenous group
**
P<0.01 compared with the intravenous group