Table 1.

High-risk prognostic features for adult ALL

	B-ALL	T-ALL
At Diagnosis
Age	>35
WBC	>30 × 109	>100 × 109
Cytogenetics	t(9;22), t(4;11), −7, +8, t(8;14) Hypodiploidy	t(1;19)*
	Complex cytogenetics
Molecular genetics	BCR-ABL IKAROS BAALC+	BAALC+ HOX11L2 ERG+
Immunophenotype	Pro B CD10-neg pre-B CD20	Early T Mature T
After Induction
Time to CR1	> 4 weeks
MRD	> 10−4
Clinical Relapse	> CR1

^*Recent report by Burmeister et. al [10]. shows no adverse prognosis with t(1;19)

WBC = white blood cell count, MRD = minimal residual disease, CR1= First complete remission