Table 3.

Estimated Effect of HIV Illness Parameters as Predictors of Emerging Symptom Cases Based on Symptom Cutoff Scores/Youth or Caregiver Report (Multivariable Logistic Regression Results)

Predictor	Levels of Predictors	Any Symptoma		ADHDb		Disruptive Behaviorsc		Major Depression or Dysthymiad		Separation or General Anxietye
		OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
Entry CD4%	25% or more vs 0–24%	0.67 (0.26, 1.76)	.42	1.11 (0.44, 2.83)	.83	0.64 (0.27, 1.49)	.30	0.36 (0.16, 0.81)	.01	0.45 (0.17, 1.16)	.10
Nadir CD4%	15% or more vs 0–14%	1.05 (0.45, 2.42)	.91	2.21 (0.89, 5.45)	.09	1.13 (0.50, 2.53)	.77	1.20 (0.53, 2.76)	.66	0.95 (0.39, 2.29)	.91
Entry RNA VL	>10,000 vs less	1.38 (0.60, 3.16)	.44	0.71 (0.31, 1.62)	.42	1.39 (0.64, 3.00)	.40	1.42 (0.63, 3.19)	.39	1.02 (0.42, 2.44)	.97
Peak RNA	>100,000 vs less	1.53 (0.63, 3.74)	.35	0.69 (0.31, 1.53)	.36	0.55 (0.24, 1.23)	.14	0.93 (0.40, 2.12)	.86	0.89 (0.36, 2.20)	.80
CDC class	C class vs other classes	1.07 (0.39, 2.94)	.90	0.63 (0.23, 1.75)	.37	1.07 (0.43, 2.66)	.88	1.90 (0.80, 4.51)	.15	1.27 (0.47, 3.46)	.63

OR, odds ratio; CI, confidence interval; CDC, Centers for Disease Control and Prevention; C, CDC Clinical Class C (severely symptomatic). Individual demographic covariates with p < .20 were considered for inclusion in a multivariable model for each disease severity factor. This resulted in a core model of covariates for all youth with PHIV.

^aAdjusted for race or ethnicity, number of life stressors.

^bAdjusted for caregiver psychiatric disorders.

^cAdjusted for gender, age at registration.

^dAdjusted for race or ethnicity.

^eAdjusted for age at registration, relationship with the caregiver.