TABLE 1.
Genes involved in cholesterol-related biological processes that are essential for normal male fertility.
| Gene name(synonym) | Gene Product | Biological Process Related to Cholesterol | Reference | Inbred Mouse Line or Hybrids (×) |
| Abca1 | ATP-binding cassette, subfamily A, member 1 | Cholesterol efflux, metabolic process, reverse transport | (41) | DBA1/J |
| Abcg5 | ATP-binding cassette, subfamily G (WHITE), member 5 | Cholesterol efflux, homeostasis, negative regulation of intestinal absorption | (117) | A/J |
| ApoB | Apolipoprotein B | Cholesterol homeostasis, metabolic process, transport, positive regulation of storage, regulation of biosynthetic process | (118) | 129S4/SvJae × C57BL/6J |
| Cftr | Cystic fibrosis transmembrane conductance regulator | Cholesterol biosynthetic process, transport | (119) | 129P2/OlaHsd |
| Crem | cAMP-responsive element modulator | Regulation of transcription, DNA dependent | (120) | 129/Sv × C57BL/6 |
| Dhcr24 | 24-dehydrocholesterol reductase | Cholesterol biosynthetic process, metabolic process | (85) | C57BL/6J × 129S5 |
| Ehd1 | EH-domain containing 1 | Cholesterol homeostasis, positive regulation of storage | (121) | 129;B6 |
| Lep | Leptin | Cholesterol metabolic process, regulation of intestinal absorption | (122) | C57BL/6J |
| Lepr | Leptin receptor | Cholesterol metabolic process | (123) | 129 × C57BL/6 |
| Lipe | Lipase, hormone-sensitive | Cholesterol metabolic process | (124) | B6 × 129S7 |
| Lrp8 (Apoe2) | LDL receptor-related protein 8, apolipoprotein e receptor | Positive regulation of CREB transcription factor activity | (107) | 129S6/SvEvTac |
| Npc1 | Niemann Pick type C1 | Cholesterol efflux, homeostasis | MGI direct data submission 2004–2007 | BALB/C |
| Nr1h2 (Lxrb) | Nuclear receptor subfamily 1, group H, member 2 | Cholesterol homeostasis, negative regulation of storage, positive regulation of efflux, positive regulation of transport | (125) | 129S6/SvEvTac × C57BL/6 |
| Nr1h3 (Lxra) | Nuclear receptor subfamily 1, group H, member 3 | Cholesterol homeostasis, negative regulation of storage, positive regulation of efflux, positive regulation of transport and homeostasis, homeostasis of sterol | (126) | 129S6/SvEvTac × C57BL/6 |
| Rxrb | Retinoid X receptor β | Regulation of transcription, DNA dependent | (42) | 129S2/SvPas |
| Sirt1 | Sirtuin1 | Cholesterol homeostasis, response to cholesterol | (127) | 129/Sv × 129S6/Sv |
Targeted, spontaneous, or ENU-induced inactivation of these genes in mouse models results in reduced fertility or infertility in males. Data are adopted from Mouse Genome Informatics database.