Fig. 1.

Mean isotopic enrichment over time of plasma apoAI for the 19 subjects before and after weight loss and multicompartmental model used to determine the kinetics of apoAI (insert). Compartments 1–4 describe the kinetic of leucine in plasma. Compartment 5 represents the intracellular pool of leucine (hepatic and other tissues) from which apoAI is synthesized and appears into the circulation (compartment 7) after a delay (compartment 6). Enrichment data in compartment 5 were used as a forcing function for the enrichment data of apoAI in the circulation.