TABLE 3.

Lipid profiles and plasma apoAI kinetic parameters before and after weight loss

Variables	Before Weight Loss	After Weight Loss	% Change	Pa
Weight (kg)b	98.3 ± 19.6	89.4 ± 18.2	−9.1%	<0.001
Waist circumference (cm)b	112.2 ± 12.2	104.3 ± 13.4	−7.0%	<0.001
VLDL-TG (mmol/l)	1.37 ± 0.53	1.03 ± 0.48	−24.8%	0.007
HDL-C (mmol/l)b	0.88 ± 0.19	0.93 ± 0.22	6.0%	0.059
HDL2-C (mmol/l)b	0.29 ± 0.09	0.30 ± 0.10	2.3%	0.684
HDL3-C (mmol/l)	0.58 ± 0.15	0.63 ± 0.15	7.9%	0.045
HDL-TG (mmol/l)	0.13 ± 0.02	0.14 ± 0.02	2.4%	0.625
HDL2-TG (mmol/l)b	0.03 ± 0.01	0.03 ± 0.01	−0.5%	0.975
HDL3-TG (mmol/l)b	0.11 ± 0.02	0.11 ± 0.02	1.5%	0.805
HDL-ApoAI (g/l)	1.03 ± 0.17	1.06 ± 0.17	2.6%	0.190
Apo-AI
PS (mg)b	4,224 ± 749	4,208 ± 702	−0.4%	0.808
Concentration (g/l)	1.18 ± 0.16	1.20 ± 0.16	2.3%	0.126
PR (mg/kg/d)	14.2 ± 2.4	14.5 ± 3.0	2.2%	0.583
FCR (pool/d)b	0.33 ± 0.06	0.30 ± 0.04	−7.8%	0.046
CETP (μg/ml)	2.81 ± 0.54	2.81 ± 0.46	−0.1%	0.978
Hepatic lipase (U/l)b	38.3 ± 93.5	36.3 ± 92.6	−5.3%	0.345
Endothelial lipase (ng/ml)b	249.7 ± 70.5	218.8 ± 52.2	−12.4%	0.078
ApoB (g/l)	1.00 ± 0.21	0.94 ± 0.20	−6.0%	0.008
Glucose (mmol/)b	6.08 ± 0.48	5.83 ± 0.41	−4.2%	<0.001
Insulin (pmol/l)b	128.4 ± 62.6	106.6 ± 50.2	−17.0%	0.034
HOMA-IR	34.5 ± 16.6	27.4 ± 12.2	−20.7%	0.030
Lathosterol/C ratio (10 μmol/mmol C)	280.4 ± 75.1	229.4 ± 85.6	−18.2%	0.002

Values are presented as mean ± SD and percent change versus the control diet before weight loss. The HOMA-IR score, apoB, glucose, and insulin concentrations have been published previously (14). Lathosterol/C ratio data have been published previously (21). C, cholesterol; CETP, cholesteryl ester transfer protein; FCR, fractional catabolic rate; HOMA-IR score = (insulin × glucose)/22.5; PR, production rate; PS, pool size; TG, triglycerides; VLDL, very low-density lipoprotein.

^aP value from the main effect of time in the mixed model (n = 19).

^bAnalysis was performed on log-transformed values.