TABLE II.

Summary of Neutral Diffusion Assay Results

Dose (mg/kg/day)	Male rats				Female rats
	No. of animals	% of cells with LMW DNA			No. of animals	% of cells with LMW DNA
		Mean	SEM	P valuea		Mean	SEM	P valuea
Total brain
0	5	1.1	0.22	—	4	0.6	0.20	—
37.5	5	1.2	0.28	0.4887b	4	0.7	0.25	0.3594b
75	5	1.0	0.30	0.7309b	5	0.8	0.22	0.2952b
150	5	0.8	0.30	0.9042b	5	0.2	0.09	0.9161b
300	4	0.8	0.28	0.8195b	3	0.7	0.26	0.3476b
Trend testc		P = 0.1372d				P = 0.5117
EMS	5	1.2	0.34	0.6447b	4	0.5	0.20	0.5781b
Liver
0	5	0.8	0.37	—	4	0.5	0.29	—
37.5	5	0.6	0.40	0.6378	4	0.0	0.00	0.9000b
75	5	1.8	0.66	0.1128	5	0.8	0.49	0.4524b
150	5	1.0	0.32	0.3469	5	0.4	0.24	0.6349b
300	4	1.0	0.71	0.3990	3	1.0	0.58	0.3143b
Trend testc		P = 0.8279				P = 0.3880d
EMS	5	1.4	0.93	0.2826	4	0.8	0.25	0.3429b
Blood
0	5	0.2	0.20	—	4	1.0	0.41	—
37.5	5	0.0	0.00	0.7262b	4	1.0	0.41	0.5000
75	5	0.6	0.24	0.2103b	5	0.6	0.24	0.7965
150	5	0.2	0.20	0.5794b	5	1.2	0.37	0.3647
300	4	0.8	0.75	0.4524b	3	0.3	0.33	0.8572
Trend testc		P = 0.4991d				P = 0.7701
EMS	5	4.0	0.45	0.0040b*	4	1.0	0.41	0.5000

Data are presented as mean ± standard error of the mean (SEM).

LMW = low molecular weight.

^*Significant at P ≤ 0.05.

^aOne-tailed independent t-test.

^bOne-tailed Mann–Whitney.

^cLinear regression.

^dKendall rank correlation.