Table 1.

Association results for the 10 selected SNPs in the discovery and replication phase and in secondary analyses

Region, SNP	Chr	Closest gene	Type	Alleles	MAF	Discovery		Replication		Combined
						Beta	P	Beta	P	Beta	P
3p25.2
rs11128603	3	PPARG	Index SNP	A → G	0.102	0.086	2.9 × 10−8	0.031	.1	0.066	9.4 × 10−8
rs1801282	3	PPARG	nsSNP	C → G	0.127	0.069	1.4 × 10−7	0.026	.1	0.052	3.1 × 10−7
7q22.1
rs2227631	7	SERPINE1	Index SNP	A → G	0.409	0.076	7.8 × 10−15	0.069	5.5 × 10−11	0.073	3.2 × 10−24
7q22.1
rs6976053	7	ACHE	Index SNP	T → C	0.478	0.054	3.4 × 10−10	0.039	2.3 × 10−4	0.048	5.8 × 10−13
rs2075756	7	TRIP6	nsSNP	A → G	0.282	0.058	2.7 × 10−9	0.043	2.8 × 10−4	0.052	5.0 × 10−12
rs314376	7	SLC12A9	Tag SNP	G → A	0.483	0.052	2.4 × 10−9	0.041	1.4 × 10−4	0.048	2.0 × 10−12
rs12672665	7	SRRT	Tag SNP	G → A	0.479	0.047	6.1 × 10−8	0.033	2.1 × 10−3	0.041	8.0 × 10−10
rs3847067	7	ACHE	Tag SNP	A → C	0.289	0.059	4.1 × 10−10	0.038	1.1 × 10−3	0.051	4.6 × 10−12
11p15.2
rs6486122	11	ARNTL	index SNP	T → C	0.311	0.051	3.0 × 10−8	0.038	9.8 × 10−4	0.046	1.7 × 10−10
rs3816360	11	ARNTL	Tag SNP	C → T	0.333	0.048	9.9 × 10−8	0.031	5.1 × 10−3	0.041	3.9 × 10−9