Table 3.
Association between PAI-1–associated SNPs and proximal gene expression in human cells and tissues
| Chr | SNP (alleles; β; P) | Gene expression | Monocytes (n = 849) | Monocytes II (n = 1490) | Macrophages (n = 614) | Mammary artery intima-media (n = 88) | Liver (n = 152) | Aortic intima-media (n = 131) | Aortic adventitia (n = 113) |
|---|---|---|---|---|---|---|---|---|---|
| 3 | rs1801282 (C → G; 0.069; 1.4 × 10−7) | PPARG | 0.061.7 × 10−2 | NS | 0.38; 1.7 × 10−50 | NS | 1.11; 2.0 × 10−2 | NS | NS |
| 7 | rs314376 (G → A; 0.052; 2.4 × 10−9) | TRIP6 | −0.08; 4.7 × 10−15 | NA; 8.3 × 10−15 | −0.04; 6.2 × 10−3 | NS | NS | NS | NS |
| UFSP1 | −0.04; 3.5 × 10−9 | NA; 1.8 × 10−12 | −0.03; 6.7 × 10−7 | NS | 1.04; 4.0 × 10−2 | NS | NS | ||
| rs2075756 (A → G; 0.058; 2.7 × 10−9) | EPHB4 | −0.14; 2.9 × 10−24 | NA; 3.4 × 10−25 | NS | NS | NS | NS | 1.08; 5.0 × 10−2 | |
| rs6976053 (T → C; 0.054; 3.4 × 10−10) | ACHE | NS | NA | NS | NS | 1.06; 2.8 × 10−4 | NS | NS | |
| MUC3A | NA | NA | NA | NS | 1.16; 1.3 × 10−17 | NS | NS | ||
| 11 | rs10832027 (A → G; 0.051; 3.1 × 10−8) | ARNTL | −0.07; 4.1 × 10−5 | NA | −0.04; 9.2 × 10−3 | NS | NS | NS | NS |
Associations between 10 SNPs (see Table 2) and proximal genes (< 200 kb) were tested. For each cell and tissue type, β and P values for the association are shown calculated according to a linear additive model. Only SNP-gene combinations with significant associations are reported (FDR < 0.05, P < .00408).
NA indicates that the gene and/or SNP is not available in the dataset; and NS, P > .05 for the association.