Table 6.

Management of dasatinib-related gastrointestinal events

Adverse event	Incidence	Recommendation
Nausea	22% (all grades); 1% (grades 3/4)	Grade 3: withdraw treatment until grade 1 toxicity is reached; antiemetic drugs, hydration and electrolytic replacement as needed
		Grade 4: withdraw treatment until grade 1 toxicity is reached; resume the drug at lower dose; antiemetic drugs, hydration and electrolytic replacement as needed.
Diarrhea	31% (all grades); 3% (grades 3/4)	Grade 3: withdraw treatment; support therapy with antidiarrheal drugs, hydration and electrolytic replacement as needed.
		Grade 4: withdraw treatment until grade 1 toxicity is reached; resume the drug at a lower dose; antidiarrheal drugs, hydration and electrolytic replacement as needed.
Gastrointestinal bleeding	3% (all grades); 1% (grades 3/4)	Interrupt treatment; transfusions as needed; resume treatment at a lower dose but with caution