Table 2.
Association between colorectal cancer and statin use among 309 cases and 294 control patients (unadjusted model) and 190 cases and 209 control patients in the adjusted model
|
Statin use |
Unadjusted model |
Adjusted model |
||||
|---|---|---|---|---|---|---|
| Cases (309) | Controls (294) |
Basic OR* (95% CI) |
Cases (194) | Controls (211) |
Adjusted OR† (95% CI) |
|
| P-value | P-value | |||||
| No use of statins |
284 |
250 |
1.0 (referent) |
154 |
145 |
1.0 (referent) |
| ≥1dispensed prescription at least 2 months pre-recruitment |
25 |
44 |
0.52 (0.31, 0.89) |
15 |
38 |
0.33 (0.15, 0.69) |
| 0.016 ** |
0.004** |
|||||
| ≥1dispensed prescription at least 7 months pre-recruitment |
24 |
38 |
0.60 (0.35, 1.04) |
14 |
32 |
0.39 (0.18, 0.85) |
| 0.067 |
0.017** |
|||||
| ≥2 dispensed prescriptions at least 2 months pre-recruitment |
24 |
38 |
0.60 (0.35, 1.03) |
14 |
32 |
0.42 (0.19, 0.92) |
| 0.064 |
0.030** |
|||||
| ≥2 dispensed prescriptions at least 7 months pre-recruitment |
23 |
34 |
0.65 (0.37, 1.14) |
13 |
28 |
0.49 (0.22, 1.08) |
| 0.135 | 0.077 | |||||
* Adjusted for matching factors (age +/−1 year), sex and region of residence). OR = Odds ratio; CI = confidence interval.
† Adjusted for matching factors ((age +/−1 year), sex and region of residence), Family history of cancer, past medical history of cancer, past medical history of bowel disease, BMI, smoking, physical activity and regular NSAID intake.
** statistically significant at p < 0.05.