Table 2.

Features of disease severity by HbF level

Clinical features	Patients with High HbF levels (≥10%) N = 80(%)	Patients with low HbF levels (<10%) N = 136 (%)	OR (95% CI)	p value
History of dactylitis
Present	53 (66.3%)	106 (77.9%)
Absent	27 (33.7%)	30 (22.1%)	1.80 (0.97-3.53)	0.060
Age at onset of dactylitis
<1 year	37 (69.8%)	78 (73.6%)
≥ 1 year	16 (30.2%)	28 (26.4%)	1.20 (0.57-2.50)	0.617
Age at diagnosis
≤ 1 year	31 (38.8%)	54 (40%)
> 1 year	49 (61.2%)	81 (60%)	1.05 (0.59-1.86)	0.857
Hospitalisations in past year
No	40 (50%)	63 (46.3%)	1.16 (0.67-2.02)	0.602
yes	40 (50%)	73 (53.7%)
Transfusions in past year
No	62 (77.5%)	92 (67.7%)	1.65 (0.87-3.13)	0.123
Yes	18 (22.5%)	44 (32.3%)
Painful episodes in past year
No	27 (33.7%)	41 (30.1%)	1.18 (0.65-2.13)	0.583
Yes	53 (66.3%)	95 (69.9%)
History of stroke
No	76 (95%)	123 (90.4%)	2.00 (0.63-6.43)	0.231
Yes	4 (5%)	13 (9.6%)