Table 3.
Association analysis of NPC1 polymorphisms with obesity, BMI, and T2D.
| Trait | Minor allele | Whole sample | Males | Females | |||
|---|---|---|---|---|---|---|---|
| P valuea | OR (95% CI)b | P valuea | OR (95% CI)b | P valuea | OR (95% CI)b | ||
| Obesity | |||||||
| rs1788799 (C/G) | G (Met) | >0.5 | 1.05 (0.87 to 1.18) | >0.5 | 1.02 (0.81 to 1.27) | >0.5 | 1.02 (0.83 to 1.27) |
| rs1805081 (A/G) | G (Arg) | >0.5 | 0.83 (0.78 to 1.25) | >0.5 | 1.06 (0.76 to 1.47) | >0.5 | 0.93 (0.67 to 1.30 |
| BMI | P valuea | BETAc | P valuea | BETAc | P valuea | BETAc | |
| rs1788799 (C/G) | G (Met) | 0.462 | 0.328 | >0.5 | 0.490 | >0.5 | 0.231 |
| rs1805081 (A/G) | G (Arg) | >0.5 | -0.411 | >0.5 | -0.343 | >0.5 | -0.450 |
| T2D | P valuea | OR (95% CI)b | P valuea | OR (95% CI)b | P valuea | OR (95% CI)b | |
| rs1788799 (C/G) | G (Met) | 0.027 | 1.24 (1.05 to 1.48) | 0.004 | 1.50 (1.15 to 1.95) | >0.5 | 1.07 (0.85 to 1.36) |
| rs1805081 (A/G) | G (Arg) | >0.5 | 1.06 (0.82 to 1.39) | >0.5 | 1.11 (0.76 to .60) | >0.5 | 1.04 (0.71 to 1.52) |
aP values were calculated using logistic or linear regression (as appropriate) with an additive model; Bonferroni-corrected P values are reported; nominally significant P values are in bold; bodds ratio and 95% confidence intervals refer to the minor allele. cregression coefficient. BMI, body mass index; OR, odds ratio; T2D, type 2 diabetes.