Table 3.
Health-related quality of life (TACQoL)1: patients with congenital hypothyroidism (CH) versus the norm population; Mean scores, Standard deviations (SD’s) and effect sizes2
| |
Total CH |
Severe CH |
Moderate/Mild CH |
Norm population |
Effect size |
|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Total | |
|
Child-report |
|
|
|
|
|
| |
n = 82 |
n = 41 |
n = 41 |
n = 449 |
|
|
Physical Functioning |
23.7 (4.8) |
23.3 (4.9) |
24.0 (4.6) |
25.2 (5.0) |
0.3 |
|
Motor Functioning |
28.3 (3.5) *** |
27.9 (3.8) *** |
28.7 (3.3) * |
29.8 (3.1) |
0.5 |
|
Autonomy |
30.9 (1.5) |
30.5 (1.7) ** |
31.3 (1.1) |
31.5 (1.5) |
0.4 |
|
Cognitive functioning |
26.5 (4.9) *** |
25.3 (5.1) *** |
27.7 (4.4) |
28.7 (3.7) |
0.6 |
|
Social Functioning |
28.6 (4.0) *** |
28.0 (4.2) *** |
29.1 (3.9) |
29.9 (2.5) |
0.5 |
|
Positive emotions |
12.6 (2.6) *** |
13.0 (2.4) |
12.2 (2.8) *** |
13.7 (2.4) |
0.5 |
|
Negative emotions |
12.0 (2.5) |
11.4 (2.6) |
12.5 (2.3) |
11.9 (2.6) |
0.0 |
|
Parent-report |
|
|
|
|
|
| |
n = 82 |
n = 41 |
n = 41 |
n = 465 |
|
|
Physical Functioning |
26.9 (4.4) |
26.5 (4.3) |
27.3 (4.3) |
27.3 (3.8) |
0.1 |
|
Motor Functioning |
29.3 (2.8) *** |
28.7 (3.2) *** |
30.0 (2.3) |
30.8 (2.3) |
0.7 |
|
Autonomy |
31.2 (1.9) |
31.1 (1.9) |
31.2 (2.0) |
31.6 (1.2) |
0.3 |
|
Cognitive functioning |
26.0 (5.2) *** |
25.1 (5.7) *** |
26.9 (4.5) ** |
29.0 (3.7) |
0.8 |
|
Social Functioning |
29.0 (3.1) ** |
28.9 (3.0) |
29.1 (3.3) |
29.9 (2.5) |
0.4 |
|
Positive emotions |
14.5 (2.1) |
14.4 (2.3) |
14.7 (2.0) |
14.7 (2.0) |
0.1 |
| Negative emotions | 11.0 (2.4) ** | 10.9 (1.8) | 11.2 (2.8) | 11.8 (2.4) | 0.3 |
1Higher scores represent better HRQoL: range 0 – 32 for physical, motor, autonomy, cognitive, social; range 0 – 16 for positive and negative moods.
2effect size (d): total CH versus norm population.
*p < 0.007: difference between CH patients and norm population according to ANOVA by group and gender.
**p < 0.001: difference between CH patients and norm population according to ANOVA by group and gender.
***p < 0.0001: difference between CH patients and norm population according to ANOVA by group and gender.