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. 2012 Oct 16;2:58. doi: 10.1186/2191-219X-2-58

Figure 8.

Figure 8

Brain-to-plasma partition coefficients (A-D) and transport clearances across the BBB (E-H). (A) VT-NLME in rats at baseline, (B) VT-NLME in rats during and after tariquidar administration, (C) VT-NLME in rats in post-inhibition scan, and (D) VT-NLME in WB in humans at baseline (VT), during and after tariquidar administration (VT (2 mg/kg)) and in post-inhibition scan (V*T(2 mg/kg)). (E) Qin and Qout in rats at baseline, (F) Qout in rats during and after tariquidar administration (3 or 15 mg/kg), (G) Qout in rats in post-inhibition scan, and (H) Qin, Qout at baseline, Qout during and after tariquidar administration (2 mg/kg), and Q*out in post-inhibition scan (2 mg/kg) in humans. *p < 0.05, **p < 0.01, ***p < 0.001; not significant p > 0.05.