Table 1.

Number of animals (n), weight at time of PET, injected doses (average ± standard deviation) of (R)-[¹¹C]verapamil for baseline and post-inhibition scans in naïve and 48-h post SE rats and different treatments with 3 or 15 mg/kg of tariquidar

	Naïve and 3 mg/kg tariquidar treated	Naïve and 15 mg/kg tariquidar treated	48-h post SE and 3 mg/kg tariquidar treated	48-h post SE and 15 mg/kg tariquidar treated	All groups
N	7	4	5	5	21
Body weight (g)	260 ± 5	307 ± 18	234 ± 14	247 ± 16	260 ± 28
Baseline (R)-[11C]verapamil (MBq)	97 ± 27	88 ± 17	84 ± 20	94 ± 25	91 ± 22
I.V. injection time (sec)	18 ± 7	39 ± 10	19 ± 2	25 ± 11	24 ± 11
Post-inhibition (R)-[11C]verapamil (MBq)	93 ± 27	101 ± 28	91 ± 9	92 ± 16	94 ± 21
I.V. injection time (sec)	18 ± 6	36 ± 5	16 ± 2	32 ± 18	24 ± 13