Table 3.
Population parameter estimates and relative standard errors (%) of the (R)-[11C]verapamil plasma model using mixed effects modeling of the WB region of interest of rats and humans
| Pharmacokinetic parameters |
Rat |
Human estimates | |
|---|---|---|---|
| Estimates | Inter-animal variability | ||
|
Vc (ml) |
38.8 |
0.162 |
2580 |
| (7.27) |
(52.3) |
(−) |
|
|
Vp1 (ml) |
141 |
0.169 |
57900 |
| (17.6) |
(23.3) |
(−) |
|
|
Vp2 (ml) |
1580 |
- |
41100 |
| (17.6) |
(−) |
||
| CL (ml·min−1) |
16.4 |
0.162 |
538 |
| (10.3) |
(52.3) |
(−) |
|
|
Q1 (ml·min−1) |
29.1 |
0.169 |
6550 |
| (7.77) |
(23.3) |
(−) |
|
|
Q2 (ml·min−1) |
22.3 |
0.162 |
5880 |
| (10.0) |
(52.3) |
(−) |
|
| Residual error plasma |
0.482 |
- |
0.654 |
| (6.93) | (−) | ||
For definition of parameters, please refer to the legend of Figure 2. The RSA are given in parentheses after the estimates.