Table 4.
Hazard ratios (HRs) and 95% confidence intervals (CIs) of hepatocellular carcinoma (HCC) according to hepatitis C virus infection status and genotype
| Anti-HCV | HCV RNA | HCV genotype | No. of subjects | No. of HCC | Person-years | Incidence (100,000 person-year) | HRa(95% CI) | HRb(95% CI) |
|---|---|---|---|---|---|---|---|---|
| Negative |
|
|
6083 |
31 |
56,516.3 |
54.9 |
1.0 (reference) |
1.0 (reference) |
| Positive |
Positive |
1 |
52 |
8 |
476.5 |
1,678.9 |
28.3 (13.0-61.5) |
29.7 (13.6-46.8) |
| |
|
2 |
84 |
1 |
850.7 |
117.6 |
2.1 (0.3-15.4) |
2.2 (0.3-16.2) |
| |
|
1 & 2 |
6 |
2 |
51.1 |
3,913.9 |
65.0 (15.5-272.3) |
68.7 (16.4-288.4) |
| Negative | 109 | 2 | 1,045.2 | 191.4 | 3.4 (0.8-14.4) | 2.6 (0.6-11.5) |
aHR: age- and sex-adjusted. bHR: age-, sex- and HBsAg positivity-adjusted. Two hundred and thirty-six subjects including 2 HCC cases had no information on anti-HCV, and were excluded from the analysis.