GTPase(s) involved
|
Rho1
|
RhoA (other phagocytic pathways use Rac1 and/or Cdc42)
|
RhoA
|
GEF(s) involved
|
Rom1, Rom2
|
various, including Vav1 and Vav328
|
?
|
formin requirement
|
Bni1 (diaphanous-related formin)
|
mDia1, mDia2 (diaphanous-related formins)29-31
|
?
|
dynamin involvement
|
Vps1? (vps1Δ is lethal in 4Δ+ENTH1 cells, but whether lethality is linked to endocytosis is unclear)
|
Dynamin-232
|
Dynamin-1
|
integrin involvement
|
Mid2? (integrin-like, with a heavily glycosylated ectodomain and a short cytoplasmic domain that signals to the cell interior)
|
β1 subunit (α4β1 and α5β1 integrins), β2 subunit (αMβ2)27,28,34
|
?
|
polarity proteins
|
polarisome complex (Spa2, Bud6 and Bni1 subunits)
|
?
|
?
|
| cargo/receptor |
? |
various receptors, including integrins |
interleukin 2 receptor (IL2R) |
