Figure 6. The chromatin remodeling factor Brg-1 is essential for serum starvation-induced DRAM expression.

(A) Brg-1 is bound to the proximal region of the DRAM promoter. ChIP assays were performed in Hep3B and HepG2 cells. (B) Serum deprivation enhances Brg-1 and Pol II binding to the DRAM promoter locus. (C) Depletion of Brg-1 using specific targeting shRNA abolishes serum deprivation induced DRAM expression.