Figure 3. Molecular modelling of the Myo7a^I487N/I487N ewaso mutation.

(A) Partial ribbon representation of a 3D model of myosin V 2DFS highlighting the Ile⁴⁸⁷ amino acid residue, which is localised to the hinge region between the head and tail domains of the protein. (B) Schematic diagram showing superimposed images of the hinge region (Myo7a^+/+ in red and the Myo7a^I487N/I487N ewaso mutation in blue) after 4 ns of molecular dynamics simulation showing a conformational change in the hinge region close to the Ile⁴⁸⁷ mutation site, showing the involvement of residues 670–673 around the hinge region causing the distortion.