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. 2012 Dec 12;7(12):e50686. doi: 10.1371/journal.pone.0050686

Table 1. Summary of short and long term effect of subcutaneous aerogel implant on local tissue.

Incubation PeriodResponse Two weeks Twenty months
Clear Pigmented Clear Pigmented
Inflammation Mild Mild Mild Mild
Fibrosis Mild Mild Mild Mild
Infection None None None None
Implant travel None None None None
Age of rat at time of extraction ∼3 months ∼2 years

Slides from both control and implant-containing rats were reviewed blindly by pathologist, specifically looking for signs of inflammation, infection, fibrosis, and implant travel.