Skip to main content
. Author manuscript; available in PMC: 2012 Dec 12.
Published in final edited form as: Curr Opin Cell Biol. 2007 Feb 20;19(2):192–198. doi: 10.1016/j.ceb.2007.02.011

Figure 3.

Figure 3

AKAP-mediated signal integration. (a) Schematic of the role AKAP–Lbc plays in integrating cAMP signaling with both PKD and Rho pathways. Activation of PKD (blue numbers): (1) AKAP-Lbc colocalizes PKD near PKC, its upstream activator; (2) PKC phosphorylates PKD; (3) Dissociation of active PKD from the AKAP platform is promoted by PKA phosphorylation of AKAP-Lbc. Rho inhibition (purple numbers): (1) PKA phosphorylation of AKAP-Lbc generates a 14-3-3 binding site; (2) binding of 14-3-3 downregulates the Rho-GEF activity of AKAP-Lbc and (3) inhibits Rho. (b) Schematic of the role WAVE1 plays in coordinating the bi-directional regulation of the Arp2/3 complex by Cdk5 and PKA. Cdk5 phosphorylation of WAVE1 leads to inhibition of Arp2/3. This is opposed by the activity of PKA.