Table IV.
Percentage of MTD recommendation and expected trial duration (in months) for the PO-CRM and the TTTE-CRM for partial orders for scenarios 1–5 based on 1000 simulated trials.
| Scenario | d 1 | d 2 | d 3 | d 4 | d 5 | d 6 | d 7 | d 8 | Duration | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | R(di) | 0.02 | 0.05 | 0.10 | 0.20 | 0.30 | 0.50 | 0.70 | 0.80 | |
| TITE | 0.00 | 0.01 | 0.22 | 0.58 | 0.18 | 0.01 | 0.00 | 0.00 | 23.50 | |
| PO-CRM | 0.00 | 0.02 | 0.25 | 0.56 | 0.16 | 0.01 | 0.00 | 0.00 | 210 | |
| PO-TITE A | 0.00 | 0.01 | 0.27 | 0.56 | 0.14 | 0.02 | 0.00 | 0.00 | 23.50 | |
| PO-TITE B | 0.00 | 0.01 | 0.24 | 0.55 | 0.17 | 0.01 | 0.01 | 0.00 | 23.54 | |
| PO-TITE C | 0.00 | 0.02 | 0.35 | 0.53 | 0.10 | 0.02 | 0.00 | 0.00 | 23.50 | |
| PO-TITE D | 0.00 | 0.03 | 0.32 | 0.53 | 0.10 | 0.02 | 0.00 | 0.00 | 23.40 | |
| 2 | R(di) | 0.08 | 0.20 | 0.30 | 0.40 | 0.52 | 0.61 | 0.76 | 0.87 | |
| TITE | 0.12 | 0.56 | 0.30 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 23.50 | |
| PO-CRM | 0.18 | 0.54 | 0.26 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 210 | |
| PO-TITE A | 0.15 | 0.54 | 0.28 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 23.50 | |
| PO-TITE B | 0.17 | 0.55 | 0.24 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 23.51 | |
| PO-TITE C | 0.18 | 0.52 | 0.27 | 0.03 | 0.00 | 0.00 | 0.00 | 0.00 | 23.50 | |
| PO-TITE D | 0.20 | 0.52 | 0.23 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 23.52 | |
| 3 | R(di) | 0.05 | 0.06 | 0.08 | 0.11 | 0.19 | 0.34 | 0.50 | 0.64 | |
| TITE | 0.00 | 0.01 | 0.04 | 0.26 | 0.55 | 0.15 | 0.00 | 0.00 | 23.50 | |
| PO-CRM | 0.00 | 0.01 | 0.05 | 0.31 | 0.46 | 0.10 | 0.07 | 0.00 | 210 | |
| PO-TITE A | 0.00 | 0.01 | 0.07 | 0.32 | 0.43 | 0.09 | 0.08 | 0.00 | 23.50 | |
| PO-TITE B | 0.00 | 0.01 | 0.06 | 0.35 | 0.42 | 0.10 | 0.06 | 0.00 | 23.54 | |
| PO-TITE C | 0.00 | 0.00 | 0.05 | 0.35 | 0.46 | 0.08 | 0.05 | 0.00 | 23.50 | |
| PO-TITE D | 0.00 | 0.00 | 0.05 | 0.41 | 0.43 | 0.06 | 0.05 | 0.00 | 23.41 | |
| 4 | R(di) | 0.20 | 0.30 | 0.38 | 0.45 | 0.56 | 0.62 | 0.75 | 0.90 | |
| TITE | 0.71 | 0.25 | 0.04 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 23.50 | |
| PO-CRM | 0.69 | 0.25 | 0.06 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 210 | |
| PO-TITE A | 0.67 | 0.28 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 23.50 | |
| PO-TITE B | 0.68 | 0.27 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 23.50 | |
| PO-TITE C | 0.59 | 0.30 | 0.10 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 23.50 | |
| PO-TITE D | 0.58 | 0.33 | 0.09 | 0.01 | 0.00 | 0.05 | 0.00 | 0.00 | 23.52 | |
| 5 | R(di) | 0.01 | 0.02 | 0.03 | 0.05 | 0.11 | 0.20 | 0.35 | 0.50 | |
| TITE | 0.00 | 0.00 | 0.00 | 0.02 | 0.34 | 0.54 | 0.11 | 0.00 | 23.50 | |
| PO-CRM | 0.00 | 0.00 | 0.00 | 0.04 | 0.33 | 0.39 | 0.22 | 0.01 | 210 | |
| PO-TITE A | 0.00 | 0.00 | 0.00 | 0.04 | 0.36 | 0.36 | 0.22 | 0.02 | 23.50 | |
| PO-TITE B | 0.00 | 0.00 | 0.00 | 0.05 | 0.34 | 0.37 | 0.22 | 0.04 | 23.46 | |
| PO-TITE C | 0.00 | 0.00 | 0.00 | 0.06 | 0.34 | 0.36 | 0.22 | 0.01 | 23.50 | |
| PO-TITE D | 0.00 | 0.00 | 0.00 | 0.04 | 0.39 | 0.37 | 0.20 | 0.01 | 23.53 |
The MTD combinations are indicated in bold type.