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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Neuropharmacology. 2012 Sep 13;65:90–100. doi: 10.1016/j.neuropharm.2012.09.005

Figure 3.

Figure 3

Body weight and following administration of control vector (closed circles) or rAAV-leptin to MBH (open circles) or VTA (closed squares) in chow-fed rats. Body weight significantly diverged from controls starting at day 8 in MBH treated group (P<0.05) and by day 9 in the VTA treated group (P<0.05) by two-way ANOVA with repeated measures and Bonferroni post-hoc analysis. Values represent the mean ± SE of 7-8 rats per group. For data presentation, the rats administered either control vector into the hypothalamus or into the VTA were combined into a single control group (rAAV-control).

Inset: Cumulative food consumption from days 4 to 9. *P<0.001 for difference with leptin treatment by one-way ANOVA with Bonferroni post-hoc analysis.