Skip to main content
. 2012 Dec 10;29(18):2798–2804. doi: 10.1089/neu.2011.2243

FIG. 7.

FIG. 7.

Survivin promotes glial proliferation. Stable expression of survivin shRNA represses proliferating cell nuclear antigen (PCNA) expression. (A) Survivin knockdown and PCNA expression were demonstrated by Western blots. Data were normalized to β-actin to control for equal protein loading. Experiments are representative of three independent trials. The right panels depict β-actin-normalized densitometric quantification of (B) survivin and (C) PCNA expression. The data were analyzed using Student's t-test (**p<0.01, *p<0.05 versus control shRNA transduced cells). (D) Stable expression of survivin shRNA represses cellular proliferation in human U87MG glial cells, compared to cells expressing control shRNA. The effect of survivin knockdown on proliferation was analyzed over a 1-week period. Experiments are representative of two independent trials. The data were analyzed using Student's t-test (**p<0.01, *p<0.05 versus control shRNA transduced cells).