FIGURE 1.

Structure of the GnRH receptor gene. The GnRH receptor gene is 15–31 kb in size depending on the species. This is primarily due to differences in intron sizes which are indicated at the top of the figure for mouse, rat, and human species. The coding sequence is boxed with the trans-membrane domains specified in black. The 5′ and 3′ untranslated regions (UTR) are designated by thick black lines whereas the two introns are specified by thick gray lines. The mature mRNA resulting from usual intron splicing is illustrated below the gene. Sizes of translated sequences included in the human mature transcript are indicated (987 bp corresponding to 328 codons excluding the stop codon). Rat and mouse translated sequences are 327 amino acids long, the exon II being three bases shorter (+523/+738).