Table 2.
The proportions of enhancers that underwent selection based on mouse-rat alignments (neutral reference: intron sites)
| Total | Under selectiona | Positively selectedb | Under selectiona/Total | Positively selectedb/Under selectiona | Positively selectedb/Total | |
|---|---|---|---|---|---|---|
| HT | 2475 | 1222 | 428 | 49.37% | 35.02% | 17.29% |
| FB | 1159 | 748 | 83 | 64.53% | 11.09% | 7.16% |
| MB | 1218 | 720 | 147 | 59.11% | 20.41% | 12.06% |
| LB | 2470 | 1449 | 301 | 58.66% | 20.77% | 12.18% |
FB: forebrain; MB: midbrain; LB: limb; HT: heart.
aA significantly unequal proportion of substituted sites were observed between enhancers and the intron sites of the neighboring gene by Fisher's exact test.
bEnhancers that underwent selection and had a higher substitution rate than the intron sites of the neighboring gene.