Table 2.
Model parameters
| Param | Description | Value(estimate) | Ref |
|---|---|---|---|
| μ1 | VC (VC) death rate | ln(2) = 9 | In vivo |
| α19 | VC killing rate by TC cells (TC) (killing) | 0.001 | Estimated |
| α17 | VC killing rate by AB (AB) molecules (killing) | 0.001 | Estimated |
| q | No. of cancer cells to inject at every vaccine administration | 50 | SimTriplex |
| γ21 | released TAA (TAA) rate by killed VC | 3 | Estimated |
| γ28 | released TAA rate by killed CC (CC) | 3 | Estimated |
| μ2 | TAA natural degradation rate | ln(2) = 9 | In vivo |
| α20 | Binding rate between TAA and APC cells | 0.0005 | Estimated |
| α27 | Binding rate between TAA and AB (IC formation) | 0.00001 | Estimated |
| γ34 | plasma B cells (B) activation rate by TH cells (TH) | 0.05 | Estimated |
| α36 | B stimulation rate by IL2 (IL2) | 0.0035 | Estimated |
| s3 | B duplication stimulation threshold due to IL2 | 400 | Estimated |
| μ3 | B cells natural death rate (half life) | ln(2) = 15 | [32] |
| γ40 | TH cells (TH) activation rate by APC (APC) cells | 0.15 | Estimated |
| α46 | TH cells stimulation rate by IL2 (IL2) (duplication) | 0.009 | Estimated |
| s1 | duplication stimulation threshold due to IL2 | 1000 | Estimated |
| α45 | TH cells cells stimulation rate by (IL12) IL12 (duplication) | 0.009 | Estimated |
| s2 | duplication stimulation threshold due to IL12 | 1000 | Estimated |
| μ4 | TH cells natural death rate (half life) | ln(2) = 15 | Estimated |
| γ51 | IL12 molecules release rate by VC | 10 | SimTriplex |
| α54 | absorbed IL12 rate by TH cells for mitotic signals | 0.00009 | Estimated |
| α59 | absorbed IL12 rate by TC cells for mitotic signals | 0.001 | Estimated |
| μ5 | IL12 molecules natural degradation rate | ln(2) = 9 | [33] |
| γ64 | IL2 release rate by TH | 5 | Estimated |
| α63 | absorbed IL2 rate by B cells for mitotic signals | 0.0001 | Estimated |
| α69 | absorbed IL2 rate by TC cells for mitotic signals | 0.0001 | Estimated |
| μ6 | IL2 molecules natural degradation rate | ln(2) = 3 | Estimated |
| γ73 | Released AB molecules rate by B cells | 3 | SimTriplex |
| α78 | AB - CC binding rate | 0.0001 | Estimated |
| α71 | AB - VC binding rate | 0.001 | Estimated |
| α72 | AB - TAA binding rate (IC formation) | = α72 | - |
| μ7 | AB natural degradation rate | ln(2) = 7 | [34] |
| cmax | CC (CC) growth saturation threshold | 107 | Estimated |
| k | CC duplication rate | 0.0226 | SimTriplex |
| p | No. of newborn CC due to transgenic nature of mice | 3 | SimTriplex |
| α88 | CC death rate due to other IS entities | 0.0000001176 | Estimated |
| α89 | CC killing rate by TC cells | 0.00004 | Estimated |
| α87 | CC killing rate by AB | 0.00004 | Estimated |
| γ91 | TC cells activation rate by VC | 0.2 | Estimated |
| α96 | TC cells duplication rate due to IL2 | 0.05 | Estimated |
| s96 | duplication stimulation threshold thanks to IL2 | 400 | Estimated |
| μ9 | TC cells natural death rate | ln(2) = 21 | [35] |
| γ02 | APC (APC) activation rate due to TAA (TAA) | 0.07 | Estimated |
| μ0 | APC natural death rate | ln(2)/15 | [36] |