Table 1.
IDH representative structures.
| Type | Organism | Short Name | Uniprot | PDB id | Resolution (Å) |
Length |
|---|---|---|---|---|---|---|
| I | Escherischia coli | EcIDH | IDH_ECOLI | 3ICD | 2.5 | 416 × 2 |
| I | Bacillus subtilis | BsIDH | IDH_BACSU | 1HQS | 1.55 | 423 × 2 |
| I | Aeropyrum pernix | ApIDH | Q9YE81_AERPE | 1TYO | 2.15 | 435 × 2 |
| I | Burcholderi apseudomallei | BpIDH | Q63WJ4_BURPS | 3DMS | 1.65 | 427 × 2 |
| II | Mycobacterium tuberculosis | MtIDH1 | IDH_MYCTU | Model | NA | 407 × 2 |
| II | Homo sapiens (cytoplasmic) | HcIDH | IDHC_HUMAN | 1T0L | 2.41 | 414 × 2 |
| II | Saccharomyces cerevisiae (mito.) | YmIDH | IDHP_YEAST | 2QFW | 2.6 | 427 × 2 |
| II | Sus scrofa (mitochondrial) | PmIDH | IDHP_PIG | 1LWD | 1.85 | 413 × 2 |
| II | Thermotoga maritima | TmIDH | Q9X0N2_THEMA | 1ZOR | 2.24 | 399 × 2 |
| IV | Thermus thermophilus | TtIDH | IDH_THET8 | 2D1C | 1.8 | 495 × 2 |
At most four representatives of each type (I, II and IV) of NADP-dependent IDH were chosen for simulation, in addition to the model of MtIDH1. Ligands and metal ions were removed, as they are different in each case. Uniprot sequences may be longer than PDB lengths given here, due to unresolved terminal residues. These residues were not modelled. Monomeric IDHs (M) were simulated but results are not discussed here. The data of the monomeric type is provided here for completeness and comparison purposes.