Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Step-wise CFTR folding pathway. (A) CFTR folding begins cotranslationally as individual domains are synthesized, and proceeds as domains assemble into a mature tertiary structure. (B) The ΔF508 mutation destabilizes NBD1 structure, interferes with the TMD1, TMD2, and NBD2 folding, and disturbs interactions between NBD1 and ICL4, compromising domain–domain assembly.
