Table 2.
Category | Experiment summary | Result summary | References |
---|---|---|---|
Lung injury | Murine hepatitis virus strain 1 (MHV-1) infection | Causing greater severity of acute lung injury (ALI)a | Han et al., 2012 |
Ventilator-induced lung injury (VILI) | Faster development of VILIb | Real et al., 2012 | |
LPS instillation | Causing greater severity of ALIa | Han et al., 2011 | |
Vascular damage | Coronary artery ligation and reperfusion | Worsen heart damagea | Salio et al., 2008 |
Atherogenic diet feed | Increased atherosclerotic lesion area in PTX3 and ApoE-double KO mice | Norata et al., 2009 | |
Ischemia and reperfusion of the superior mesenteric artery | Prevent tissue injury and mortalitya | Souza et al., 2009 | |
Increased tissue injury and mortalityb | Souza et al., 2002 | ||
Infection | LPS-induced endotoxemia | Increased survival ratiob | Dias et al., 2001 |
CLP-induced sepsis | Increased survival ratiob | Dias et al., 2001 | |
Pulmonary infection by Aspergillus fumigatus | Decreased survival ratioa | Garlanda et al., 2002 | |
Pulmonary infection by Klebsiella pneumoniae | Faster lethality by a high inoculum administrationb | Soares et al., 2006 | |
Delayed lethality by a mid-to-low inoculum administrationb | Soares et al., 2006 | ||
Murine cytomegalovirus (MCMV) infection | More susceptible to MCMV infectiona | Bozza et al., 2006 | |
Influenza virus infection | More susceptible to influenza virus infectiona | Reading et al., 2008 | |
Others | Fas-deficient (lpr) C57BL/6 (B6) mice with mild lupus-like autoimmunity | Aggravate autoimmune lung disease in PTX3-KO B6Lpr mice | Lech et al., 2011 |
Kidney ischemia reperfusion injury | Less kidney injury and inflammationa | Chen et al., 2012 | |
Subcutaneous injection of Matrigel containing FGF2 and/or TSG-6 | Abolishing of vascularization inhibition in PTX-KO mice | Leali et al., 2012 | |
Rolling interaction of PMNs in the mesenteric venules | Increased rolling interaction frequencya | Deban et al., 2010 | |
Sexual system | Subfertilea | Varani et al., 2002 | |
Kainate-induced seizures | More widespread seizure-related neuronal damage in the forebrain of PTX3-KO mice | Ravizza et al., 2001 |
PTX3-knockout mouse study.
PTX3-transgenic mouse study.