Table 2.

Responses to certain disorders in PTX3-knockout and PTX3-transgenic mice.

Category	Experiment summary	Result summary	References
Lung injury	Murine hepatitis virus strain 1 (MHV-1) infection	Causing greater severity of acute lung injury (ALI)a	Han et al., 2012
	Ventilator-induced lung injury (VILI)	Faster development of VILIb	Real et al., 2012
	LPS instillation	Causing greater severity of ALIa	Han et al., 2011
Vascular damage	Coronary artery ligation and reperfusion	Worsen heart damagea	Salio et al., 2008
	Atherogenic diet feed	Increased atherosclerotic lesion area in PTX3 and ApoE-double KO mice	Norata et al., 2009
	Ischemia and reperfusion of the superior mesenteric artery	Prevent tissue injury and mortalitya	Souza et al., 2009
		Increased tissue injury and mortalityb	Souza et al., 2002
Infection	LPS-induced endotoxemia	Increased survival ratiob	Dias et al., 2001
	CLP-induced sepsis	Increased survival ratiob	Dias et al., 2001
	Pulmonary infection by Aspergillus fumigatus	Decreased survival ratioa	Garlanda et al., 2002
	Pulmonary infection by Klebsiella pneumoniae	Faster lethality by a high inoculum administrationb	Soares et al., 2006
		Delayed lethality by a mid-to-low inoculum administrationb	Soares et al., 2006
	Murine cytomegalovirus (MCMV) infection	More susceptible to MCMV infectiona	Bozza et al., 2006
	Influenza virus infection	More susceptible to influenza virus infectiona	Reading et al., 2008
Others	Fas-deficient (lpr) C57BL/6 (B6) mice with mild lupus-like autoimmunity	Aggravate autoimmune lung disease in PTX3-KO B6Lpr mice	Lech et al., 2011
	Kidney ischemia reperfusion injury	Less kidney injury and inflammationa	Chen et al., 2012
	Subcutaneous injection of Matrigel containing FGF2 and/or TSG-6	Abolishing of vascularization inhibition in PTX-KO mice	Leali et al., 2012
	Rolling interaction of PMNs in the mesenteric venules	Increased rolling interaction frequencya	Deban et al., 2010
	Sexual system	Subfertilea	Varani et al., 2002
	Kainate-induced seizures	More widespread seizure-related neuronal damage in the forebrain of PTX3-KO mice	Ravizza et al., 2001

^aPTX3-knockout mouse study.

^bPTX3-transgenic mouse study.