Table 3.
NET component proteins | Proteomic identification of PTX3 complex in sepsis | ||
---|---|---|---|
Cellular localization | Protein name | Gene name | |
Granules | Neutrophil elastase | ELANE | |
Lactotransferrin | LTF | ||
Azurocidin | AZU1 | Yes | |
Cathepsin G | CTSG | ||
Myeloperoxidase | MPO | Yes | |
Proteinase 3 | PRTN3 | ||
Lysozyme C | LYZ | ||
Neutrophil defensin 1 and 3 | DEFA1 and 3 | Yes (DEFA1) | |
Pentraxin 3 | PTX3 | Target protein | |
Bactericidal permeability-increasing protein | BPI | ||
Cathelicidin anti-microbial peptide | CAMP | ||
Nucleus | Histone H1 | H1F0 | |
Histone H2A | H2A | Yes | |
Histone H2B | H2B | ||
Histone H2B-like | H2B | ||
Histone H3 | H3 | Yes | |
Histone H4 | H4 | Yes | |
Myeloid cell nuclear differentiation antigen | MNDA | ||
Cytoplasm | S100 calcium-binding protein A8 | S100A8 | |
S100 calcium binding protein A9 | S100A9 | ||
S100 calcium-binding protein A12 | S100A12 | ||
Cytoskeleton | Actin (beta and/or gamma 1) | ACTB, ACTG1 | Yes |
Myosin-9 | MYH9 | Yes | |
Alpha-actinin (1 and/or -4) | ACTN1, ACTN4 | ||
Plastin-2 | LCP1 | ||
Cytokeratin-10 | KRT10 | Yes | |
Peroxisomal | Catalase | CAT | |
Glycolytic enzymes | Alpha-enolase | ENO1 | Yes |
Transketolase | TKT | Yes |