Table 3.
List of the NET component proteins and proteins belonging to the PTX3 complex.
| NET component proteins | Proteomic identification of PTX3 complex in sepsis | ||
|---|---|---|---|
| Cellular localization | Protein name | Gene name | |
| Granules | Neutrophil elastase | ELANE | |
| Lactotransferrin | LTF | ||
| Azurocidin | AZU1 | Yes | |
| Cathepsin G | CTSG | ||
| Myeloperoxidase | MPO | Yes | |
| Proteinase 3 | PRTN3 | ||
| Lysozyme C | LYZ | ||
| Neutrophil defensin 1 and 3 | DEFA1 and 3 | Yes (DEFA1) | |
| Pentraxin 3 | PTX3 | Target protein | |
| Bactericidal permeability-increasing protein | BPI | ||
| Cathelicidin anti-microbial peptide | CAMP | ||
| Nucleus | Histone H1 | H1F0 | |
| Histone H2A | H2A | Yes | |
| Histone H2B | H2B | ||
| Histone H2B-like | H2B | ||
| Histone H3 | H3 | Yes | |
| Histone H4 | H4 | Yes | |
| Myeloid cell nuclear differentiation antigen | MNDA | ||
| Cytoplasm | S100 calcium-binding protein A8 | S100A8 | |
| S100 calcium binding protein A9 | S100A9 | ||
| S100 calcium-binding protein A12 | S100A12 | ||
| Cytoskeleton | Actin (beta and/or gamma 1) | ACTB, ACTG1 | Yes |
| Myosin-9 | MYH9 | Yes | |
| Alpha-actinin (1 and/or -4) | ACTN1, ACTN4 | ||
| Plastin-2 | LCP1 | ||
| Cytokeratin-10 | KRT10 | Yes | |
| Peroxisomal | Catalase | CAT | |
| Glycolytic enzymes | Alpha-enolase | ENO1 | Yes |
| Transketolase | TKT | Yes | |