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. 2013 Jan;92(1):51–57. doi: 10.1177/0022034512466263

Figure 4.

Figure 4.

MEK1/ERK signaling is required for endothelial differentiation of SHED in vitro. (A) Qualitative analysis of the morphology of SHED cells treated with differentiation medium in the presence of U0126 or LY294002. (B) Western blot showing the effect of Akt inhibition with LY294002 or (C) the effect of ERK inhibition with U0126 on endothelial cell differentiation of SHED, as determined by VEGFR2 expression. (D) Effects of 2 different shRNA-MEK1 sequences (a,b) on silencing of MEK1 in SHED cells. (E) Effect of MEK1 silencing on endothelial cell differentiation of SHED, as determined by VEGFR2 expression. (F) Schematic diagram depicting the signaling pathways studied here.