Table 5.
Biological networks in kidney graft tissues that are associated with BKVN.
| GO term | Genes annotated | P value* | |
|---|---|---|---|
| Negative regulation of transcription | GO:0048661 | EDN1, TNF | 0.003 |
| Positive regulation of NF kappa B transcription | GO:0016481 | TGFB1, TNF | 0.004 |
| Activation of MAPK activity | GO:0051092 | IKBKB, TGFB1, TNF | 0.005 |
| Positive regulation of phosphorylation | GO:0000187 | IL1B, TNF | 0.007 |
| Intracellular signal transduction | GO:0001934 | IL1B, TNF | 0.007 |
| Negative regulation of viral genome replication | GO:0007242 | CD80, IL8 | 0.008 |
| Signal transducer activity | GO:0045071 | CCL5, TNF | 0.010 |
| Organ morphogenesis | GO:0004871 | CCL2, CCL3, CCL5, HMOX1, IL12B, IL13, IL15, IL18, IL1A, IL1B, STAT3 | 0.011 |
| Positive regulation of transription, DNA dependent | GO:0009887 | CCL2, IL7, TGFB1, TNF | 0.011 |
| Transcription activator activity | GO:0045941 | CD80, CD86, TNF | 0.011 |
| Exocytosis | GO:0016563 | CD80, CD86, IKBKB, TGFB1 | 0.011 |
| Chemoattractant activity | GO:0006887 | CCL3, CCL5 | 0.013 |
| Angiogenesis | GO:0042056 | CCL3, CCL5 | 0.013 |
| Induction of positive chemotaxis | GO:0001525 | IL18, IL1B, IL8, VEGF | 0.013 |
| Regulation of cell adhesion | GO:0050930 | IL8, VEGF | 0.015 |
| Regulation of isotype switching | GO:0030183 | IL10, IL4 | 0.015 |
| Regulation of cell adhesion | GO:0045191 | IL10, IL4 | 0.015 |
| Response to oxidative stress | GO:0030155 | ICAM1, IL18, IL8 | 0.016 |
| Protein phosphorylation | GO:0006979 | CCL5, PTGS2 | 0.016 |
| Positive regulation of T helper 2 cell differentiation | GO:0006468 | CCL2, IKBKB, TGFB1 | 0.017 |
| Cellular component movement | GO:0045630 | CD86, IL6 | 0.018 |
| Positive regulation of B cell proliferation | GO:0006928 | ACTB, CCL3, CCL5, CXCR3, IFNG, IL13, IL8, PTGS2, STAT3 | 0.019 |
| Cellular calcium ion homeostasis | GO:0030890 | IL4, IL7, PTPRC | 0.019 |
| Chemokine activity | GO:0006874 | CCL19, CCL2, CCL3, CCL5 | 0.022 |
| Response to glucocorticoid stimulus | GO:0008009 | CCL19, CCL2, CCL3, CCL5, CXCL10, CXCL11, IL8 | 0.024 |
| Positive regulationof T cell proliferation | GO:0051384 | IL10, IL6, TNF | 0.024 |
| T cell differentiation | GO:0042102 | CD28, CD3E, IL12A, IL4, PTPRC | 0.024 |
| Defense response to virus | GO:0030217 | IL2, PTPRC | 0.025 |
| Induction of apoptosis by extracellular signals | GO:0051607 | BCL2, PTPRC | 0.026 |
| Negative regulation of transcription from RNA polymerase II promoter | GO:0008624 | CD38, FAS, FASLG | 0.027 |
| Positive regulation of protein kinase activity | GO:0000122 | SMAD3, STAT3, TNF | 0.030 |
| Response to virus | GO:0045860 | CD4, PTPRC | 0.033 |
| Negative regulation of cytokine secretion involved in immune response | GO:0009615 | CCL19, CCL5, IFNG, TNF | 0.033 |
| Negative regulation of interleukin-6 production | GO:0002740 | IL10, TNF | 0.033 |
| Receptor biosynthetic process | GO:0032715 | IL10, TNF | 0.033 |
| Positive regulation of cytokine production | GO:0032800 | IL10, TNF | 0.033 |
| Positive regulation of transcription from RNA polymerase II promoter | GO:0050715 | IL10, TNF | 0.033 |
| Positive regulation of isotype switching to IgG isotypes | GO:0045944 | IL4, IL6, SMAD3, TNF | 0.034 |
| Regulation of immune response | GO:0048304 | IFNG, IL4, TBX21 | 0.035 |
| Activation of caspase activity | GO:0050776 | IFNG, IL4, TBX21 | 0.035 |
| Receptor binding | GO:0006919 | BAX, SMAD3, TNF | 0.035 |
| Antigen processing and presentation | GO:0005102 | C3, REN | 0.038 |
| Activation a proapoptotic gene products | GO:0019882 | CD8A, IFNG | 0.038 |
| Cell cycle arrest | GO:0008633 | BCL2, FAS, FASLG | 0.039 |
| Protein kinase binding | GO:0007050 | IFNG, IL12A, IL12B, IL8, SMAD3, TGFB1 | 0.042 |
| Cell adhesion | GO:0019901 | CD3E, CD4, PTPRC | 0.043 |
| JAK-STAT cascade | GO:0007155 | CCL2, CCL5, CD34, CD4, CXCR3, FN1, SELE, SELP | 0.044 |
| Plasma membrane | GO:0007259 | CCL2, CCR2, STAT3 | 0.046 |
| Neutrophil chemotaxis | GO:0005886 | ACE, AGTR1, AGTR2, CCR2, CCR4, CCR5, CCR7, CD19, CD28, CD34, CD38, CD3E, CD4, CD40, CD40LG, CD80, CD86, CD8A, CSF1, CXCR3, FAS, FASLG, ICAM1, ICOS, IL2RA, PTPRC, SELE, SELP, TFRC, TNF, TNFRSF18 | 0.046 |
| Positive regulation of interleukin-2 biosynthetic process | GO:0045086 | IFNG, IL1B, IL8 | 0.046 |
*P values by ANOVA followed by Bonferroni adjustment.