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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Neurotoxicology. 2012 Feb 9;33(3):272–279. doi: 10.1016/j.neuro.2012.01.015

Figure 3. Nrf2-ARE regulated proteins are increased for 6 weeks after a single treatment of siKeap1.

Figure 3

A) Four different siRNA sequences all unique to Keap1 (siKeap1 1-4) and siNT were administered for 24 hours and tested for hPAP reporter activity in confluent astrocyte culture 3 weeks post treatment. * p<0.05, siKeap1 vs siNT. B) hPAP reporter activity and C) NQO1 activity was assayed from 4-42 days after a single 24 hour treatment with siKeap1 (black bars), siNT (light grey bars) or tBHQ (dark grey bars) in confluent astrocytes. * p<0.05, siKeap1 vs siNT; #p<0.05, tBHQ vs siNT.