Skip to main content
. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Circ Cardiovasc Genet. 2012 Apr 24;5(3):293–300. doi: 10.1161/CIRCGENETICS.111.961136

Figure 1.

Figure 1

Genetic linkage analyses for loci that modify membranous and muscular VSD susceptibility in Nkx2-5+/- animals from the C57Bl/6 X FVB/N F2 population. An example of each VSD type is shown. (A) At least three significant membranous VSD modifier loci exist on chromosomes 6, 8 and 10. Genome-wide significance thresholds are indicated by the dotted lines (α = 0.001 and 0.05). (B) Genetic linkage analysis for muscular VSD modifier loci reveals a significant overlap of the chromosome 6 peak with a membranous VSD locus. The significance thresholds shown were determined by permutation of genotypes on chromosomes 6, 8 and 10, which contain the membranous VSD modifier loci. N = 233 membranous VSDs, 80 muscular VSDs, and 284 structurally normal hearts.