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. Author manuscript; available in PMC: 2012 Dec 13.
Published in final edited form as: J Med Chem. 2011 Oct 3;54(20):7375–7384. doi: 10.1021/jm2009937

Scheme 2. Assembly of the trivalent construct on solid support.

Scheme 2

Reagents and conditions: (a) 7, HCTU, DIEA, DMF; (b) 100% TFA; (c) 20% DIEA in DCM; (d) Boc-linker-OH, HCTU, DIEA, DMF; (e) N3CH2CO2H, HBTU, DIEA, DMF; (f) CuI, Ascorbic acid, DIEA, peptide (A) or (B), (Cf. Figure 2 for the sequences), DMF:2,6-Lutidine; (g) HF.