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Influence of valency on affinity.
| Compound | IC50 (nM) | Relative potency to NB397 |
|---|---|---|
| NB397-1×MSH(4) | 4900 ± 760 | - |
| NB399-2×MSH(4) | 310 ± 73 | 16 |
| NB341-3×MSH(4) | 14 ± 1.5 | 350 |
Competition experiments were carried out using time resolved fluorescence31. Multimers were competed against Eu-NDP-α-MSH. The IC50 values are the average of 4 experiments each done in quadruplicate.
